Another Option for Fibroid Management

This study evaluated results of long-term treatment of uterine fibroids with ulipristal acetate, a selective progesterone receptor modulator.

Ulipristal acetate is a steroid that reversibly binds to the progesterone receptor and selectively modulates its activity. It was shown in previous studies to successfully control fibroid-related symptoms preoperatively in women scheduled to undergo surgical treatment.

This study evaluated the benefits of long-term ulipristal acetate administration as medical management of fibroid symptoms. Premenopausal women with fibroids between 3 and 12 cm and menorrhagia were randomly assigned to receive ulipristal acetate 5 mg, ulipristal acetate 10 mg, or placebo for four 12-week courses. After each 12-week course, a drug-free period was held, and the new course started with the second menstruation during the pill-free period.

Read more about the Ulipristal acetate study.

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