Women With Cervical Cancer at Reduced Distant Recurrence Risk After Adjuvant Chemotherapy, Study Shows
Women with node-positive stage IB-IIB cervical cancer who received systemic chemotherapy post-surgery were at a reduced risk of distant recurrence, according to results from a retrospective study of Japanese women published in the International Journal of Cancer.
Systemic chemotherapy following surgery for clinical stage IB-IIB cervical cancer with pelvic and/or para-aortic lymph node metastasis was independently associated with decreased risk of distant recurrence after 5 years (19.2%) compared with chemoradiation (24.6%; adjusted hazard ratio [HR], 0.47; 95% CI 0.31-0.71, P <.001) and radiation alone (22.1%). There were 239 cases of distant recurrence with para-aortic lymph nodes (9.3%), lung (7.5%), and thoracic/cervical lymph nodes (5.5%) as the most common sites.
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